Successful treatment of pregnant women with syphilis and penicillin allergy
نویسندگان
چکیده
Background Congenital syphilis (CS) is a transplacentally transmitted infection caused by Treponema pallidum that occurs in infants of untreated or inadequately treated mothers. The preferred treatment for syphilis in pregnant mothers is penicillin. In patients with a history of penicillin allergy, skin testing and oral challenge should be performed. Penicillin desensitization is indicated for pregnant women with syphilis who demonstrate immediate hypersensitivity to this drug.
منابع مشابه
Successful desensitization to penicillin after diagnostic reassessment.
Clinical situations for which penicillin is indicated as the sole effective treatment are not infrequent, in these circumstances penicillin allergy complicates their medical management. No proven alternatives to penicillin are available for treating neurosyphilis, congenital syphilis, or syphilis in pregnant women, it is not possible choosing an alternative non betalactam antibiotic. The manage...
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OBJECTIVE To estimate the risk of serious adverse reactions to benzathine penicillin in pregnant women for preventing congenital syphilis. METHODS We searched for clinical trials or cohorts that assessed the incidence of serious adverse reactions to benzathine penicillin in pregnant women and the general population (indirect evidence). MEDLINE, EMBASE, Scopus and other databases were searched...
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